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Inadequate/Considerable Metabolizers, CYP2D6 The development on the active metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Close to 7% with the populace has minimized action on the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme technique. These people are “weak metabolizers” of debrisoquine, dextromethorphan and tricyclic